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Curriculum
2000 BS in Biology (Neurobiology), Universidad Complutense de Madrid, Madrid, Spain
2003 PhD in Neurosciences, Luis M. Garcia-Segura Lab, Cajal Institute, Madrid, Spain
2004-2006 Postdoctoral Fellow, Bruce S. McEwen Lab, Rockefeller University, NY
2006-present Postdoctoral Associate, Mirjana Maletic-Savatic Lab, Stony Brook University, NY
Awards
2001 Top 10 Student by the Universidad Complutense de Madrid
2001 Best School report by the Official Association of Biologist of Madrid
2003 PhD Thesis Extraordinary Award, Universidad Complutense de Madrid
2005 Young Investigator Award in the Workshop on Steroid Hormones and Brain Function, Breckenridge, CO
2007 Press Release, Society for Neuroscience Meeting
2007 Associate Member, New York Academy of Sciences
Publications
Gottfried-Blackmore A, Sierra A, McEwen BS, Bulloch K. (in review). Microglia express functional 11beta-Hydroxysteroid Dehydrogenase Type 1
Gottfried-Blackmore A, Sierra A, Jellinck PH, McEwen BS, Bulloch K. 2008. Brain microglia express steroid-converting enzymes in the mouse. Journal of Steroid Biochemistry and Molecular Biology 109 (1-2): 96-107
Sierra A, Gottfried-Blackmore A, Herrick S, Milner T, McEwen BS, Bulloch K. 2008. Steroid hormone receptor expression and function in microglia. Glia 56:659-674.
Sierra A, Gottfried-Blackmore A, McEwen BS, Bulloch K. 2007. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55:412-424.
Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM. 2005. Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration. Journal of Neural Transmission 112 (1):171-6.
Sierra A. 2004. Neurosteroids: The StAR protein in the brain. Journal of Neuroendocrinology, Young Investigator Perspectives, 16 (9): 787-793.
Garcia-Segura LM, Veiga S, Sierra A, Melcangi, RC, Azcoitia I. 2003. Aromatase: a neuroprotective enzyme. Progress in Neurobiology 71 (1): 31-41.
Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM. 2003. Aromatase expression by reactive astroglia is neuroprotective. Annals of the New York Academy of Sciences 1007: 298-305.
Perez-Martin M, Azcoitia I, Trejo JL, Sierra A, Garcia-Segura LM. 2003. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. European Journal of Neuroscience 18 (4): 923-30.
Sierra A, Lavaque E, Perez-Martin M, Azcoitia I, Hales DB, Garcia-Segura LM. 2003. Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury. European Journal of Neuroscience 18 (6): 1458-67.
Sierra A, Azcoitia I, Garcia-Segura LM. 2003. Endogenous estrogen formation is neuroprotective in a model of cerebellar ataxia. Endocrine 21: 43.51.
Azcoitia I, Sierra A, Veiga S, Honda S, Harada N, Garcia-Segura LM. 2001. Brain Aromatase is Neuroprotective. Journal of Neurobiology 47:318-329.
Azcoitia I, Fernandez-Galaz C, Sierra A, Garcia-Segura LM. 1999. Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration. Journal of Neurocytology 28:699-710
Azcoitia I, Sierra A, Garcia-Segura LM. 1999. Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling. Journal of Neuroscience Research 58:815-822
Azcoitia I, Sierra A, Garcia-Segura LM. 1999. Localization of estrogen receptor immunoreactivity in astrocytes of the adult rat brain. Glia 26:260-267
Azcoitia I, Sierra A, Garcia-Segura LM. 1998. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. Neuroreport 9:3075-3079.